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A compelling and troubling exploration of a generation raised on antidepressants, and a book that combines expansive interviews with substantive research-based reporting, Coming of Age on Zoloft is a vitally important and immediately engrossing study of one of America’s most pressing and omnipresent issues: our growing reliance on prescription drugs. Of age have not been established. Safety and effectiveness of ZYPREXA and fluoxetine in combination in children of age have not been established.(8.4) See 17 for PATIENT COUNSELING INFORMATION and Medication Guide. Revised: 2/2021 FULL PRESCRIBING INFORMATION: CONTENTS. WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS.

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Coming Of Age On Zoloft

Author :Katherine Sharpe
ISBN :9780062059741
Genre :Biography & Autobiography
File Size : 28.20 MB
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A compelling and troubling exploration of a generation raised on antidepressants, and a book that combines expansive interviews with substantive research-based reporting, Coming of Age on Zoloft is a vitally important and immediately engrossing study of one of America’s most pressing and omnipresent issues: our growing reliance on prescription drugs. Katherine Sharpe, the former editor of Seed magazine’s ScienceBlogs.com, addresses the questions that millions of young men and women are struggling with. “Where does my personality end and my prescription begin?” “Do I have a disease?” “Can I get better on my own?” Combining stout scientific acumen with first-person experience gained through her own struggle with antidepressants, Sharpe leads the reader through a complex subject, a guide towards a clearer future for all.

The Sage Encyclopedia Of Pharmacology And Society

Author :Sarah E. Boslaugh
ISBN :9781483349992
Genre :Health & Fitness
File Size : 76.30 MB
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The SAGE Encyclopedia of Pharmacology and Society explores the social and policy sides of the pharmaceutical industry and its pervasive influence in society. While many technical STM works explore the chemistry and biology of pharmacology and an equally large number of clinically oriented works focus on use of illegal drugs, substance abuse, and treatment, there is virtually nothing on the immensely huge business (“Big Pharma”) of creating, selling, consuming, and regulating legal drugs. With this new Encyclopedia, the topic of socioeconomic, business and consumer, and legal and ethical issues of the pharmaceutical industry in contemporary society around the world are addressed. Key Features: 800 signed articles, authored by prominent scholars, are arranged A-to-Z and published in a choice of electronic or print formats Although arranged A-to-Z, a Reader's Guide in the front matter groups articles by thematic areas Front matter also includes a Chronology highlighting significant developments in this field All articles conclude with Further Readings and Cross References to related articles Back matter includes an annotated Resource Guide to further research, a Glossary, Appendices (e.g., statistics on the amount and types of drugs prescribed, etc.), and a detailed Index The Index, Reader’s Guide, and Cross References combine for search-and-browse capabilities in the electronic edition The SAGE Encyclopedia of Pharmacology and Society is an authoritative and rigorous source addressing the pharmacology industry and how it influences society, making it a must-have reference for all academic libraries as a source for both students and researchers to utilize.

Psychiatric Medication And Spirituality

Author :Lynne Vanderpot
ISBN :9781784503918
Genre :Religion
File Size : 51.95 MB
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Challenging an exclusively medical approach to mental health and illness, this book considers the impact psychiatric drugs can have on spirituality. In the last thirty years, a dramatic rise in medication as a treatment for mental illness has occurred in tandem with increasing numbers of people entering treatment with a spiritually-oriented understanding of their suffering. The unforeseen result is that some people taking psychiatric drugs are engaging with them in ways that can have a profound impact on the course and outcome of treatment. Based on interviews with people on psychiatric medication who regard spirituality as significant in their lives, this book reveals how medication can be perceived as both helpful and harmful to spirituality. The author argues that spirituality must be considered in debates around psychopharmacology.

Wet Dreams And Zoloft

Author :Jason Madsen
ISBN :1411691776
Genre :Fiction
File Size : 31.48 MB
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Wet Dreams and Zoloft is a humorous coming-of-age novel by Jason Madsen that aims its guns right at Generation Rx. Somewhat based on the author’s own experiences with agoraphobia and panic disorder, the book follows a young teenager who’s afraid of…well, just about everything.Eighteen-year-old Kyle Crane is pretty much the poster boy for problems. His mother went crazy and ran off to Spain, his father has been missing for years, and he hasn’t left his house in…well, for as long as he can remember—but his mom keeps paying the bills, so he’s not complaining. If those things weren’t bad enough, one day an interesting mishap with a tennis ball introduces him to Angela, a free-spirited, and sometimes…aggressive young girl who makes it her mission in life to bug the hell out of him. Before he knows it, Kyle finds himself on a road trip with Angela to California to find his missing father, and hopefully some answers to his problems.

Lost Connections

Author :Johann Hari
ISBN :9781526634085
Genre :Psychology
File Size : 35.4 MB
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THE INTERNATIONAL BESTSELLER 'A book that could actually make us happy' SIMON AMSTELL 'This amazing book will change your life' ELTON JOHN 'One of the most important texts of recent years' BRITISH JOURNAL OF GENERAL PRACTICE 'Brilliant, stimulating, radical' MATT HAIG 'The more people read this book, the better off the world will be' NAOMI KLEIN 'Wonderful' HILLARY CLINTON 'Eye-opening' GUARDIAN 'Brilliant for anyone wanting a better understanding of mental health' ZOE BALL 'A game-changer' DAVINA MCCALL 'Extraordinary' DR MAX PEMBERTON 'Beautiful' RUSSELL BRAND Depression and anxiety are now at epidemic levels. Why? Across the world, scientists have uncovered evidence for nine different causes. Some are in our biology, but most are in the way we are living today. Lost Connections offers a radical new way of thinking about this crisis. It shows that once we understand the real causes, we can begin to turn to pioneering new solutions – ones that offer real hope.

How To Disappear Completely

Author :Kelsey Osgood
ISBN :9781468308464
Genre :Biography & Autobiography
File Size : 76.78 MB
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She devoured their memoirs and magazine articles, committing the most salacious details to memory to learn what it would take to be the very best anorexic. When she was hospitalized at fifteen, she found herself in an existential wormhole: how can one suffer from something one has actively sought out? With attuned storytelling and unflinching introspection, Kelsey Osgood unpacks the modern myths of anorexia as she chronicles her own rehabilitation. How to Disappear Completely is a brave, candid and emotionally wrenching memoir that explores the physical, internal, and social ramifications of eating disorders.

Compromising The Ideals Of Science

Author :R. Sassower
ISBN :9781137519429
Genre :Social Science
File Size : 80.21 MB
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This books examines the conditions under which scientists compromised the ideals of science, and elucidates these with reference to the challenges of profit motives and national security concerns. The book also offers suggestions for changing the political and economic conditions under which the integrity of science and its ethos can be practiced.

Ethical Issues In Behavioral Neuroscience

Author :Grace Lee
ISBN :9783662448663
Genre :Medical
File Size : 36.73 MB
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Behavioral neuroscience encompasses the disciplines of neurobiology and psychology to study mechanisms of behavior. This volume provides a contemporary overview of the current state of how ethics informs behavioral neuroscience research. There is dual emphasis on ethical challenges in experimental animal approaches and in clinical and nonclinical research involving human participants.

Coming Of Age

Author :Cheryl L. Sisk
ISBN :9780190669065
Genre :Medical
File Size : 67.64 MB
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Contemporary neuroscience has made remarkable strides in our understanding of the developing adolescent brain--an area of study previously reserved for developmental psychologists and pediatric endocrinologists. With an eye toward the history and future of the field, Coming of Age takes a look at the research that brought about this paradigm shift. Current advances in neuroscience have changed the way we think about everything--from how drugs and stress influence adolescent development to how hormones cause differing developmental trajectories among females and males. Sisk and Romeo guide students and non-specialist researchers alike through the basic science of brain and behavioral development. Important social and ethical questions are raised including: Why does puberty continue to occur at a younger age? Why does teenage behavior embrace risk and volatility? When does adolescent development end? And how should our understanding of adolescent development affect the juvenile justice system?

Coming Of Age At The End Of Days

Author :Alice LaPlante
ISBN :9780802191342
Genre :Fiction
File Size : 48.56 MB
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A girl is lured into fanaticism in this psychological thriller with “stunning twists”—by the New York Times–bestselling author of Turn of Mind (San Francisco Chronicle). Never one to conform, Anna always had trouble fitting in. Earnest and willful, she quickly learned, as a young girl, how to hide her quirks from her parents and friends. But at sixteen, a sudden melancholia takes hold of her life. Then the Goldschmidts move in next door. The new neighbors are active members of a religious cult, and Anna is awestruck by both their son, Lars, and their fervent violent prophecies for the Tribulation at the End of Days. Within months, Anna’s life—her family, her home, her very identity—will undergo profound changes. But when her newfound beliefs threaten to push her over the edge, she must find her way back to the center, in this “crisp meditation on the deadly mixture of mental illness and religious charlatanism” (San Francisco Chronicle). “LaPlante crafts prose that cuts to the quick and is the perfect vehicle for this dark tale. . . . A compelling read.” —The Seattle Times

Military Neuroscience And The Coming Age Of Neurowarfare

Author :Armin Krishnan
ISBN :9781317096061
Genre :Political Science
File Size : 31.63 MB
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Krishnan describes military applications of neuroscience research and emerging neurotechnology with relevance to the conduct of armed conflict and law enforcement. This work builds upon literature by scholars such as Moreno and Giordano and fills an existing gap, not only in terms of reviewing available and future neurotechnologies and relevant applications, but by discussing how the military pursuit of these technologies fits into the overall strategic context. The first to sketch future neurowarfare by looking at its potentials as well as its inherent limitations, this book’s main theme is how military neuroscience will enhance and possibly transform both classical psychological operations and cyber warfare. Its core argument is that nonlethal strategies and tactics could become central to warfare in the first half of the twenty-first century. This creates both humanitarian opportunities in making war less bloody and burdensome as well as some unprecedented threats and dangers in terms of preserving freedom of thought and will in a coming age where minds can be manipulated with great precision.

The Girl Who Doesn T Talk

Author :Susanna Klein
ISBN :9781475964677
Genre :Biography & Autobiography
File Size : 34.58 MB
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Susanna Klein never meant to insist on silence. But after the shy and sensitive little girl entered school and rarely spoke out loud, she was labeled as “the girl who doesn’t talk.” Helplessly trapped within her quiet world, Susanna taught herself how to talk without moving her lips. Sadly, no one understood her suffering or her condition: selective mutism. In her compelling memoir, Susanna shares not only her powerful life story, but also her painful yet authentic journey inside her innermost thoughts as she details how her profound shyness permeated every area of her life and held her back from many of life’s best experiences. As she embarks on a coming-of-age journey into adulthood, Susanna soon realizes she is stuck, unable to move on in her relationships or career. Desperate for answers but without any idea of where to turn, Susanna has no idea she is about to be saved by a sunny, golden little boy. The Girl Who Doesn’t Talk offers a touching, informative look at one woman’s journey to redeem her painful past as she gains the understanding, self-acceptance, and peace that finally allows her to walk confidently into her future.

New York

Author :
ISBN :STANFORD:36105022620103
Genre :New York (N.Y.)
File Size : 76.86 MB
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Shit My Dad Says

Author :Justin Halpern
ISBN :9780752227498
Genre :Fiction
File Size : 54.41 MB
Format :PDF, Docs
Download :310
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'At 28 years old, I found myself living at home, with my 73-year-old father. As a child, my father never minced words, and when I screwed up, he had a way of cutting right through the bullshit and pointing out exactly why I was being an idiot. When I moved back in I was still, for the most part, an idiot. But this time, I was smart enough to write down all the things he said to me..' Meet Justin Halpern and his dad. Almost 1.5 million people follow Mr Halpern’s philosophical musings every day on Twitter, and in this book, his son weaves a brilliantly funny, touching coming-of-age memoir around the best of his sayings. What emerges is a chaotic, hilarious, true portrait of a father and son relationship from a major new comic voice. As Justin says at one point, his dad is ‘like Socrates, but angrier, and with worse hair’; and this is the sort of shit he says.. ‘You know, sometimes it’s nice having you around. But now ain’t one of those times. Now gimmie the remote, we’re not watching this bullshit.’ ‘Happy Birthday, I didn’t get you a present.. Oh, mom got you one? Well, that’s from me then, too – unless it’s shitty.’ ‘Your brother brought his baby over this morning. He told me it could stand. It couldn’t stand for shit. Just sat there. Big let down.’ ‘The worst thing you can be is a liar . . . Okay, fine, yes, the worst thing you can be is a Nazi, but THEN, number two is liar. Nazi 1, Liar 2.’ ‘Why the f**k would I want to live to 100? I’m 73 and shit’s starting to get boring. By the way, there’s no money left when I go, just fyi.’

After Everything

Author :Suellen Dainty
ISBN :9781476771380
Genre :Fiction
File Size : 21.96 MB
Format :PDF, Mobi
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For readers who were swept away by Under the Tuscan Sun, charmed by Le Divorce, and intrigued by The Descendants, here is a “moving, dangerous, shrewd, and un-putdown-able story” (Robert Drewe, author of Our Sunshine) about midlife coming-of-age. They’ve been the best of friends for decades and seen everything—marriage, divorce, success, and bankruptcy. They think that there are no more surprises, that they’ve learned all of life’s lessons. But they’re wrong. They’ve only just begun. Recently divorced and seeking to find herself, Penny moves to a picturesque town in France, happy to live alone—that is until she meets an irresistible American philosophy professor. Meanwhile, handsome bachelor Peter falls head over heels for the first time in his life with curvaceous, sexy, and fiercely independent Frieda; Tim and Angie face challenges in their childless, co-dependent marriage; and Jeremy, twice divorced and the most successful of them all, struggles with a destructive addiction. At the heart of the story is Sandy, Penny’s ex-husband and once an acclaimed songwriter. Realizing perhaps too late that he’s taken his wife and children for granted, he attempts to reconcile with his son and daughter. But before he can make amends with them, Sandy has to confront a secret tragedy that has haunted him, and his relationships, for decades. Wonderfully wise and deeply engaging, After Everything is “an absorbing read” (Kirkus Reviews) about the frailties and joys of friendship and family and the struggle of learning how to live in a changing world.

Prison Break

Author :Dorothy Woods
ISBN :1462889603
Genre :Religion
File Size : 39.59 MB
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Your mind confi nes you as a Prison. In the deepest corners of the brain are chambers prohibiting access to freedom. The effects of your mind creating a mental prison limits behavior thus giving rise to an equally stagnant mental prison. Negative and positive variables, controlled and uncontrolled stimuli, are examined cognitively and cross examined with obtrusive and unobtrusive behavior. Biblical perspectives are reviewed in relation to the Creator and His purpose of mankind. Decision making processes are examined for biological and psychological development.

American Band

Author :Kristen Laine
ISBN :9781101216972
Genre :Biography & Autobiography
File Size : 23.89 MB
Format :PDF, Kindle
Download :674
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In the spirit of Friday Night Lights comes the stirring story of a marching band from small-town middle America. Every fall, marching bands take to the field in a uniquely American ritual. For millions of kids, band is a rite of passage—a first foray into leadership and adult responsibility, and a chance to learn what it means to be a part of a community. Nowhere is band more serious than at Concord High School in Elkhart, Indiana, where the entire town is involved with the success of its defending state champion band, the Marching Minutemen. In the place where this tradition may have originated, in the city that became the band instrument capital of the world, band is a religion. But it’s not the only religion—as legendary director Max Jones discovers when conflicting notions of faith and purpose collide during his final year as director. In this intimate chronicle, the band marches through a season that starts in hope and promise, progresses through uncertainty and disappointment, and ends, ultimately, in redemption.

Musicological Identities

Author :Jacqueline Warwick
ISBN :9781351556743
Genre :Music
File Size : 48.96 MB
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No music scholar has made as profound an impact on contemporary thought as Susan McClary, a central figure in what has been termed the 'new musicology'. In this volume seventeen distinguished scholars pay tribute to her work, with essays addressing three approaches to music that have characterized her own writings: reassessing music's role in identity formation, particularly regarding gender, sexuality, and race; exploring music's capacity to define and regulate perceptions and experiences of time; and advancing new modes of analysis more appropriate to those aspects and modes of musicking ignored by traditional methods. Contributors include, in overlapping categories, many fellow pioneers, current colleagues, and former students, and their essays, like McClary's own work, address a wide range of repertories ranging from the established canon to a variety of popular genres. The collection represents the generational arrival of the 'new' musicology into full maturity, dividing fairly evenly between pre-eminent scholars of music and a group of younger scholars who have already made their mark in significant ways. But the collection is also, and fundamentally, interdisciplinary in nature, in active conversation with such fields as history, anthropology, philosophy, aesthetics, media studies, film music studies, dramatic criticism, women's studies, and cultural studies.

Who We Might Ve Been

Author :D. L. Pitchford
ISBN :9780998794556
Genre :Fiction
File Size : 66.13 MB
Format :PDF, ePub, Mobi
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Mental Illness

Author :Lorraine Savage
ISBN :9780737745993
Genre :Young Adult Nonfiction

Coming Of Age On Zoloft Pdf Free Download Free

File Size : 55.56 MB
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This volume explores the issues surrounding mental illness. Readers are presented with diversity of opinion on this topic, including both conservative and liberal points of view in an even balance. Readers will learn about the causes and diagnosis of mental disorders. They will evaluate effective treatment methods. Readers will also learn about a woman who survives with schizophrenia, and another who lives with bipolar disorder.

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Medically reviewed by Drugs.com. Last updated on Nov 30, 2020.

In Summary

Commonly reported side effects of tramadol include: pruritus, agitation, anxiety, constipation, diarrhea, hallucination, nausea, tremor, vomiting, and diaphoresis. Other side effects include: insomnia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to tramadol: oral capsule extended release, oral capsule extended release 24 hr, oral suspension, oral tablet, oral tablet extended release

Warning

Oral route (Tablet; Tablet, Extended Release; Capsule, Extended Release; Solution)

Addiction, Abuse, and Misuse

TraMADol hydrochloride exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient's risk prior to prescribing traMADol hydrochloride, and monitor all patients regularly for the development of these behaviors or conditions.

Opioid Analgesic Risk Evaluation and Mitigation Strategy (REMS)

To ensure that the benefits of opioid analgesics outweigh the risks of addiction, abuse and misuse, the Food and Drug Administration (FDA) has required a REMS for these products. Under the requirements of the REMS, drug companies with approved opioid analgesic products must make REMS-compliant education programs available to healthcare providers. Healthcare providers are strongly encouraged to: complete a REMS-compliant education program, counsel patients and/or their caregivers, with every prescription, on safe use, serious risks, storage, and disposal of these products, emphasize to patients and their caregivers the importance of reading the Medication Guide every time it is provided by their pharmacists, and consider other tools to improve patient, household, and community safety.

Life-Threatening Respiratory Depression

Serious, life-threatening, or fatal respiratory depression may occur with use of traMADol hydrochloride. Monitor for respiratory depression, especially during initiation of traMADol hydrochloride or following a dose increase. Instruct patients to swallow traMADol hydrochloride extended release formulations intact, and not to cut, break, chew, crush, or dissolve the tablets to avoid exposure to a potentially fatal dose of traMADol.

Accidental Ingestion

Accidental ingestion of even one dose of traMADol hydrochloride, especially by children, can result in a fatal overdose of traMADol.

Ultra-Rapid Metabolism of TraMADol and Other Risk Factors for Life-Threatening Respiratory Depression in Children

Life-threatening respiratory depression and death have occurred in children who received traMADol. Most of the reported cases occurred following tonsillectomy and/or adenoidectomy, and many of the children had evidence of being an ultra-rapid metabolizer of traMADol due to a CYP2D6 polymorphism. TraMADol hydrochloride tablets are contraindicated in children younger than 12 years of age and in children younger than 18 years of age following tonsillectomy and/or adenoidectomy. Avoid the use of traMADol hydrochloride tablets in adolescents 12 to 18 years of age who have other risk factors that may increase their sensitivity to the respiratory depressant effects of traMADol.

Neonatal Opioid Withdrawal Syndrome

Prolonged use of traMADol hydrochloride during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. If opioid use is required for a prolonged period in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available.

Interactions with Drug Affecting Cytochrome P450 Isoenzymes

The effects of concomitant use or discontinuation of CYP3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with traMADol are complex. Use of CYP3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with traMADol hydrochloride requires careful consideration of the effects on the parent drug, traMADol, and the active metabolite, M1.

Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants

Concomitant use of opioids with benzodiazepines or other CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of traMADol hydrochloride and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation.

Side effects requiring immediate medical attention

Along with its needed effects, tramadol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tramadol:

Less common

  • Abnormal or decreased touch sensation
  • blisters under the skin
  • blood in the urine
  • blood pressure increased
  • blurred vision
  • change in walking and balance
  • chest pain or discomfort
  • chills
  • dark urine
  • difficult urination
  • dizziness or lightheadedness when getting up from a lying or sitting position
  • fainting
  • frequent urge to urinate
  • gaseous stomach pain
  • loss of memory
  • numbness and tingling of the face, fingers, or toes
  • pain in the arms, legs, or lower back, especially pain in the calves or heels upon exertion
  • pain or discomfort in the arms, jaw, back, or neck
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pale, bluish-colored or cold hands or feet
  • recurrent fever
  • seeing, hearing, or feeling things that are not there
  • severe cramping
  • severe nausea
  • severe redness, swelling, and itching of the skin
  • stomach fullness
  • sweating
  • swelling of the hands, ankles, feet, or lower legs
  • trembling and shaking of the hands or feet
  • trouble performing routine tasks
  • weak or absent pulses in the legs
  • yellow eyes or skin

Incidence not known

  • Agitation
  • confusion
  • cough
  • darkening of the skin
  • difficulty swallowing
  • dizziness
  • fever
  • hives, itching, skin rash
  • loss of appetite
  • mental depression
  • nausea
  • overactive reflexes
  • poor coordination
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • restlessness
  • shivering
  • talking or acting with excitement you cannot control
  • tightness in the chest
  • twitching
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking tramadol:

Symptoms of overdose

  • Change in consciousness
  • decreased awareness or responsiveness
  • difficulty with breathing
  • lack of muscle tone
  • lightheadedness
  • loss of consciousness
  • pinpointed pupils of the eyes
  • severe sleepiness
  • slow or irregular heartbeat
  • unusual tiredness

Side effects not requiring immediate medical attention

Some side effects of tramadol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • discouragement
  • drowsiness
  • dry mouth
  • feeling of warmth
  • feeling sad or empty
  • feeling unusually cold
  • general feeling of discomfort or illness
  • irritability
  • itching or skin rash
  • joint pain
  • loss of interest or pleasure
  • loss of strength or weakness
  • muscle aches and pains
  • redness of the face, neck, arms, and occasionally, upper chest
  • sleepiness or unusual drowsiness
  • stomach pain
  • stuffy nose
  • tiredness
  • trouble concentrating
  • unusual feeling of excitement
  • weakness

Less common

  • Abnormal dreams
  • appetite decreased
  • bladder pain
  • blistering, crusting, irritation, itching, or reddening of the skin
  • bloody or cloudy urine
  • body aches or pain
  • change in hearing
  • clamminess
  • cough producing mucus
  • cracked, dry, or scaly skin
  • decreased interest in sexual intercourse
  • difficult, burning, or painful urination
  • difficulty with moving
  • disturbance in attention
  • ear congestion
  • ear drainage
  • earache or pain in the ear
  • excessive gas
  • falls
  • false or unusual sense of well-being
  • feeling hot
  • feeling jittery
  • general feeling of bodily discomfort
  • goosebumps
  • headache, severe and throbbing
  • hoarseness
  • inability to have or keep an erection
  • itching, pain, redness, swelling, tenderness, or warmth on the skin
  • joint sprain, stiffness, or swelling
  • loss in sexual ability, desire, drive, or performance
  • loss of voice
  • lower back or side pain
  • muscle aching or cramping
  • muscle injury
  • muscle pain, stiffness, spasms, or twitching
  • pain in the limbs
  • pain or tenderness around the eyes and cheekbones
  • pain, swelling, or redness in the joints
  • skin discoloration
  • trouble in holding or releasing urine
  • trouble sleeping
  • weight changes

For Healthcare Professionals

Applies to tramadol: oral capsule extended release, oral tablet, oral tablet disintegrating, oral tablet extended release

General

The most common adverse reactions include nausea, constipation, dry mouth, somnolence, dizziness, and vomiting.[Ref]

Psychiatric

CNS stimulation has been reported as a composite of nervousness, anxiety, agitation, tremor, spasticity, euphoria, emotional lability, and hallucinations. During clinical trials, tolerance development was mild and the reports of a withdrawal syndrome were rare. Symptoms of a withdrawal syndrome have included: panic attacks, severe anxiety, hallucinations, paraesthesias, tinnitus and unusual CNS symptoms (i.e. confusion, delusions, personalization, derealization, and paranoia).[Ref]

Very common (10% or more): CNS stimulation (up to 14%)

Common (1% to 10%): Anxiety, euphoria, nervousness, sleep disorder, insomnia, depression, agitation, apathy, depersonalization

Rdp for mac port. Uncommon (0.1% to 1%): Emotional lability

Rare (less than 0.1%): Hallucinations, nightmares, dependency

Very rare (less than 0.01%): Withdrawal syndrome[Ref]

Hypersensitivity

Rare (less than 0.1%): Anaphylaxis, allergic reactions such as dyspnea, bronchospasm, wheezing, angioneurotic edema, swollen skin[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 40%), constipation (up to 46%), vomiting (up to 17%), dyspepsia (up to 13%)

Common (1% to 10%): Dry mouth, diarrhea, abdominal pain, flatulence, sore throat, gastroenteritis viral

Uncommon (0.1% to 1%): Toothache, appendicitis, pancreatitis[Ref]

Nervous system

Epileptiform seizures primarily occurred following administration of high doses or following concomitant treatment with drugs that lower the seizure threshold or trigger seizures.

Serotonin syndrome has been reported during concomitant use of opioids with serotonergic drugs.[Ref]

Very common (10% or more): Dizziness (up to 28%), somnolence (up to 25%), headache (up to 32%),

Common (1% to 10%): Confusion, coordination disturbance, tremor, paresthesia, hypoesthesia

Uncommon (0.1% to 1%): Migraine, sedation, syncope, disturbance in attention

Rare (less than 0.1%): Epileptiform seizures

Postmarketing reports: Seizures

Opioids:

Postmarketing reports: Serotonin syndrome[Ref]

Dermatologic

Very common (10% or more): Pruritus (up to 11%)

Common (1% to 10%): Sweating, rash, dermatitis

Uncommon (0.1% to 1%): Cellulitis, piloerection, clamminess, urticaria, toxic epidermal necrolysis, Stevens Johnson-syndrome, hair disorder, skin disorder[Ref]

Genitourinary

Common (1% to 10%): Menopausal symptoms, urinary frequency, urinary retention, urinary tract infection

Uncommon (0.1% to 1%): Difficulty in micturition, hematuria, dysuria, cystitis, sexual function abnormality[Ref]

Cardiovascular

Very common (10% or more): Flushing (up to 15.8%)

Common (1% to 10%): Vasodilation, postural hypotension, chest pain

Uncommon (0.1% to 1%): Palpitations, myocardial infarction, lower limb edema, peripheral swelling, hypertension, increased heart rate, peripheral ischemia, EKG abnormality, hypotension, tachycardia

Rare (less than 0.1%): Bradycardia

Postmarketing reports: QT prolongation/torsade de pointes[Ref]

Reports of QT prolongation and/or torsade de pointes have been received. In many cases, patients were taking another drug associated with QT prolongation, had risk factors for QT prolongation such as hypokalemia, or in the overdose setting.[Ref]

Other

Very common (10% or more): Asthenia (up to 12%)

Common (1% to 10%): Malaise, weakness, pain, feeling hot, influenza like illness, rigors, lethargy, pyrexia

Uncommon (0.1% to 1%): Tinnitus, vertigo, ear infection[Ref]

Metabolic

Common (1% to 10%): Anorexia, decreased weight, increased blood glucose

Uncommon (0.1% to 1%): Gout

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Rare (less than 0.1%): Changes in appetite[Ref]

Endocrine

Very rare (less than 0.01%): Syndrome of inappropriate antidiuretic hormone secretion

Opioids:

Postmarketing reports: Adrenal insufficiency; androgen deficiency[Ref]

Hematologic

Uncommon (0.1% to 1%): Anemia, ecchymosis[Ref]

Hepatic

Uncommon (0.1% to 1%): Cholelithiasis, cholecystitis, ALT and AST increased, abnormal liver function tests[Ref]

Ocular

Common (1% to 10%): Miosis, visual disturbance, blurred vision

Uncommon (0.1% to 1%): Lacrimation disorder

Frequency not reported: Mydriasis[Ref]

Renal

Uncommon (0.1% to 1%): blood urea nitrogen increased[Ref]

Musculoskeletal

Common (1% to 10%): Hypertonia, arthralgia, back pain, limb pain, neck pain, muscle cramps, muscle spasms, joint stiffness, muscle twitching, myalgia, aggravated osteoarthritis

Uncommon (0.1% to 1%): Joint swelling, joint sprain, muscle injury, leg cramps

Rare (less than 0.1%): Involuntary muscle contractions[Ref]

References

1. Cerner Multum, Inc. 'UK Summary of Product Characteristics.' O 0

2. Cerner Multum, Inc. 'Australian Product Information.' O 0

3. 'Product Information. Ultram ER (traMADol).' PriCara Pharmaceuticals, Raritan, NJ.

4. 'Product Information. Ultram (tramadol).' McNeil Pharmaceutical, Raritan, NJ.

Frequently asked questions

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